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Index > Protein center > Xdh(Gene name) > Rat
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  • Xdh (Gene name),
  • Xanthine dehydrogenase/oxidase (Protein name ),  XDH_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Xdh;
    Protein name:
    Xanthine dehydrogenase/oxidase;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with BTN1A1.
    Function:
    Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
    Subcellular Location:
    Peroxisome Cytoplasm Secreted
    Protein Attributes:
    Sequence length:
    1331
    Sequence:
    50:
    MTADELVFFV | NGKKVVEKNA | DPETTLLVYL | RRKLGLCGTK | LGCGEGGCGA | 
    100:
    CTVMISKYDR | LQNKIVHFSV | NACLAPICSL | HHVAVTTVEG | IGNTQKLHPV | 
    150:
    QERIARSHGS | QCGFCTPGIV | MSMYTLLRNQ | PEPTVEEIEN | AFQGNLCRCT | 
    200:
    GYRPILQGFR | TFAKDGGCCG | GSGNNPNCCM | NQTKDQTVSL | SPSLFNPEDF | 
    250:
    KPLDPTQEPI | FPPELLRLKD | TPQKKLRFEG | ERVTWIQAST | MEELLDLKAQ | 
    300:
    HPDAKLVVGN | TEIGIEMKFK | NMLFPLIVCP | AWIPELNSVV | HGPEGISFGA | 
    350:
    SCPLSLVESV | LAEEIAKLPE | QKTEVFRGVM | EQLRWFAGKQ | VKSVASIGGN | 
    400:
    IITASPISDL | NPVFMASGAK | LTLVSRGTRR | TVRMDHTFFP | GYRKTLLRPE | 
    450:
    EILLSIEIPY | SKEGEFFSAF | KQASRREDDI | AKVTSGMRVL | FKPGTIEVQE | 
    500:
    LSLCFGGMAD | RTISALKTTP | KQLSKSWNEE | LLQSVCAGLA | EELQLAPDAP | 
    550:
    GGMVEFRRTL | TLSFFFKFYL | TVLQKLGRAD | LEDMCGKLDP | TFASATLLFQ | 
    600:
    KDPPANVQLF | QEVPKDQSEE | DMVGRPLPHL | AANMQASGEA | VYCDDIPRYE | 
    650:
    NELSLRLVTS | TRAHAKITSI | DTSEAKKVPG | FVCFLTAEDV | PNSNATGLFN | 
    700:
    DETVFAKDEV | TCVGHIIGAV | VADTPEHAQR | AARGVKITYE | DLPAIITIQD | 
    750:
    AINNNSFYGS | EIKIEKGDLK | KGFSEADNVV | SGELYIGGQE | HFYLETNCTI | 
    800:
    AVPKGEAGEM | ELFVSTQNTM | KTQSFVAKML | GVPDNRIVVR | VKRMGGGFGG | 
    850:
    KETRSTVVST | ALALAAHKTG | RPVRCMLDRD | EDMLITGGRH | PFLAKYKVGF | 
    900:
    MKTGTVVALE | VAHFSNGGNT | EDLSRSIMER | ALFHMDNAYK | IPNIRGTGRI | 
    950:
    CKTNLPSNTA | FRGFGGPQGM | LIAEYWMSEV | AITCGLPAEE | VRRKNMYKEG | 
    1000:
    DLTHFNQKLE | GFTLPRCWDE | CIASSQYLAR | KREVEKFNRE | NCWKKRGLCI | 
    1050:
    IPTKFGISFT | LPFLNQGGAL | VHVYTDGSVL | LTHGGTEMGQ | GLHTKMVQVA | 
    1100:
    SRALKIPTSK | IHISETSTNT | VPNTSPTAAS | ASADLNGQGV | YEACQTILKR | 
    1150:
    LEPFKKKKPT | GPWEAWVMDA | YTSAVSLSAT | GFYKTPNLGY | SFETNSGNPF | 
    1200:
    HYFSYGVACS | EVEIDCLTGD | HKNLRTDIVM | DVGSSLNPAI | DIGQVEGAFV | 
    1250:
    QGLGLFTMEE | LHYSPEGSLH | TRGPSTYKIP | AFGSIPIEFR | VSLLRDCPNK | 
    1300:
    RAIYASKAVG | EPPLFLASSI | FFAIKDAIRA | ARAQHGDNAK | QLFQLDSPAT | 
    1331:
    PEKIRNACVD | QFTTLCVTGV | PENCKSWSVR | I
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    E0760b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    E0760h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    E0760r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    E0760m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    E0760c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    U0760m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    U0760r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    U0760h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    U0760b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    U0760c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Polyclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    P0760Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    P0760Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Polyclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Cat.:
    P0760Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Monoclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Monoclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Monoclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Monoclonal Antibody for Rat Xanthine dehydrogenase/oxidase
    Protein for Rat Xanthine dehydrogenase/oxidase
    Protein for Rat Xanthine dehydrogenase/oxidase
    Protein for Rat Xanthine dehydrogenase/oxidase
    Protein for Rat Xanthine dehydrogenase/oxidase
    Protein for Rat Xanthine dehydrogenase/oxidase

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    Precision
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    Linearity
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    References
    1. 1.
      "Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin."
      Amaya Y. , Yamazaki K. , Sato M. , Noda K. , Nishino T. , Nishino T.
      J. Biol. Chem.265:14170-14175(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;ENZYME REGULATION;PROTEOLYTIC CONVERSION;SUBUNIT
      tissue: Liver.
    2. 2.
      "Identification of the rat xanthine dehydrogenase/oxidase promoter."
      Chow C.W. , Clark M. , Rinaldo J. , Chalkley R.
      Nucleic Acids Res.22:1846-1854(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-55
      strain: Sprague-Dawley.
    3. 3.
      "Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells."
      Frederiks W.M. , Vreeling-Sindelarova H.
      Acta Histochem.104:29-37(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    4. 4.
      "Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant."
      Nishino T. , Okamoto K. , Kawaguchi Y. , Hori H. , Matsumura T. , Eger B.T. , Pai E.F. , Nishino T.
      J. Biol. Chem.280:24888-24894(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF MUTANT ALA-535/ARG-992/SER-1324 IN COMPLEX WITH FAD; URIC ACID AND IRON-SULFUR CENTERS;CATALYTIC ACTIVITY;DISULFIDE BOND;ENZYME REGULATION;MUTAGENESIS OF CYS-535; CYS-992 AND CYS-1316;COFACTOR
    5. 5.
      "Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase."
      Asai R. , Nishino T. , Matsumura T. , Okamoto K. , Igarashi K. , Pai E.F. , Nishino T.
      J. Biochem.141:525-534(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF MUTANT ALA-335/LEU-336 IN COMPLEX WITH FAD AND IRON-SULFUR CENTER;MUTAGENESIS OF 335-TRP-PHE-336;CATALYTIC ACTIVITY;FUNCTION;COFACTOR
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